Are presently available insulin analogues clinically beneficial?
نویسندگان
چکیده
منابع مشابه
Characterisation of insulin analogues therapeutically available to patients.
The structure and function of clinical dosage insulin and its analogues were assessed. This included 'native insulins' (human recombinant, bovine, porcine), 'fast-acting analogues' (aspart, glulisine, lispro) and 'slow-acting analogues' (glargine, detemir, degludec). Analytical ultracentrifugation, both sedimentation velocity and equilibrium experiments, were employed to yield distributions of ...
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N Engl J Med 2005;352:174-83. Copyright © 2005 Massachusetts Medical Society. he discovery of insulin more than 80 years ago is considered one of the greatest medical breakthroughs of the 20th century. 1 The first commercial insulin preparations contained numerous impurities and varied in potency from lot to lot by as much as 25 percent. Manufacturing techniques improved rapidly, however, which...
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Different kinds of insulin analogues, both short acting as well as long acting, are now available which offer several benefits over human insulins including improved physiologic profile, greater convenience, reduced risk of hypoglycemia and, in some instances, less weight gain. Combined, these elements may increase a patient’s adherence to treatment, potentially increasing the level of glycemic...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1997
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051416